Methylene Blue Treatment for Alzheimer’s Disease? A Look at the Research

Alzheimer’s disease is one of the most prevalent neurodegenerative disorders, affecting millions worldwide. With no cure currently available, researchers are exploring various treatment avenues—including an unexpected candidate: Methylene Blue (MB).

What is Methylene Blue?

Methylene Blue is a well-known compound with a long history in medicine. Originally used as a dye and antiseptic, it has been FDA-approved for treating conditions like malaria and certain psychiatric disorders. More recently, researchers have been investigating its potential neuroprotective effects, particularly in Alzheimer’s treatment.

How Might Methylene Blue Work Against Alzheimer’s Disease?

Alzheimer’s disease is characterized by neurofibrillary tangles (clumps of tau protein) and beta-amyloid plaques in the brain. These abnormal protein accumulations disrupt normal neural function, leading to memory loss and cognitive decline.

Studies suggest that MB may help combat Alzheimer’s disease through several mechanisms:

1. Prevents Tau Aggregation – MB appears to inhibit tau protein clumping, a key factor in Alzheimer’s progression.
2. Reduces Oxidative Stress – It has antioxidant properties that may protect neurons from damage.
3. Improves Mitochondrial Function – MB may enhance brain cell energy production, potentially slowing cognitive decline.

What Do Clinical Trials Show?

A review of randomized controlled trials (RCTs) showed promising but mixed results. Five out of six RCTs indicated that MB improved cognitive function and reduced beta-amyloid plaque buildup. Some studies reported significant benefits at specific doses, while others did not find conclusive evidence of improvement. It’s important for all patients taking higher dose methylene blue to get a glucose 6 phosphate dehydrogenase (G6PD) test.

Interestingly, research suggests that low doses of MB may be more effective than higher doses, which could explain inconsistencies in trial results. The exact dose to use is an ongoing area of research. Because of this we start at a low dose and work up checking on the patient frequently. MB may also be combined with photo biomodulation for enhanced benefits and we’re doing inhouse research on this Grid.

Related Read by Dr. Steve: Methylene Blue Benefits in Longevity Medicine

For more information on how to start prescription grade Methylene blue safely under medical supervision please contact our office 303.884.7557