What is Chelation and How Does it Work Using chelation therapy for the treatment of heart disease is still considered to be an experimental treatment even though the most recent study showed benefit. Chelation therapy is FDA only approved for toxic metal poisoning and hypercalcemia (a condition of too much calcium). Chelation literally means "to chemically bind to." Chelation can be administered either orally or intravenously but oral bioavailability is poor. Chelation may help but this depends on many factors. I have noticed that it is most effective when elevated levels of reactive metals are present. Several theories have been proposed for how this treatment may work. One theory suggests that EDTA chelation might work by directly removing calcium found in fatty plaques that block the arteries, causing the plaque to decrease in volume. Another is that the process of chelation may stimulate the release of a hormone (calcitonin) that in turn causes calcium to be removed from the plaques and redistributed. A third theory is that chelation therapy may work by reducing the damaging effects of oxygen ions and reactive transition metals (oxidative stress) on the walls of the blood vessels. Reducing oxidative stress could reduce inflammation in the...